Status:
COMPLETED
Study of Markers of Cosmic Radiation Exposure and Effect Among Flight Crews
Lead Sponsor:
National Cancer Institute (NCI)
Collaborating Sponsors:
Centers for Disease Control and Prevention
National Institute for Occupational Safety and Health (NIOSH/CDC)
Conditions:
Frequency of Chromosome Aberrations
Eligibility:
MALE
25-60 years
Brief Summary
Ionizing radiation efficiently induces chromosomal aberrations (CA) and several studies of CA have now been conducted among small groups of flight crews. However, most of the studies only evaluated th...
Detailed Description
Ionizing radiation efficiently induces chromosomal aberrations (CA) and several studies of CA have now been conducted among small groups of flight crews. However, most of the studies only evaluated th...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- PILOTS:
- Subjects will be Chicago based pilots who fly international flights out of Chicago.
- Subjects must have worked at least 10 years as an international pilot.
- EXTERNAL COMPARISON GROUP:
- Subjects must be currently employed as university faculty from the Chicago area.
- Pilots and External Comparison Group Subjects:
- Age 35-54.
- Non-Smoker (less than 100 lifetime cigarettes).
- Male.
- EXCLUSION CRITERIA:
- PILOTS AND EXTERNAL COMPARISON GROUP SUBJECTS:
- No personal history of cancer.
- No history of chemotherapy.
- No history of major diagnostic radiation therapy (e.g., radio-imaging that exposed the large bones or lymph nodes except for routine medical and dental x-rays).
- No family history of hereditary diseases (ataxia telangiectasia, Fanconi's anemia, Bloom's syndrome, and xeroderma pigmentosum).
- EXTERNAL COMPARISON GROUP SUBJECTS:
- Must not have a history of excessive past air travel (defined as no more than an average of one international flight/year and one domestic flight/month).
- No history of major illnesses, such as heart disease and diabetes.
- Must not have been employed in a clinical or laboratory area that involves exposure to radiation and chemotherapeutic drugs.
Exclusion
Key Trial Info
Start Date :
November 9 2001
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 3 2020
Estimated Enrollment :
134 Patients enrolled
Trial Details
Trial ID
NCT00341900
Start Date
November 9 2001
End Date
April 3 2020
Last Update
April 7 2020
Active Locations (1)
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1
National Institute for Occupational Safety and Health
Cincinnati, Ohio, United States, 26505-2888