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Status:

COMPLETED

Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human Parturition

Lead Sponsor:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Conditions:

Preterm Birth

Premature Rupture of Membranes

Eligibility:

All Genders

Brief Summary

The understanding of the biological mechanisms underlying preterm birth is very limited, making prevention of preterm birth difficult. The incidence of preterm birth worldwide varies between 6%-11% in...

Detailed Description

The understanding of the biological mechanisms underlying preterm birth is very limited, making prevention of preterm birth difficult. The incidence of preterm birth worldwide varies between 6%-11% in...

Eligibility Criteria

Inclusion

  • INCLUSION CRITERIA:
  • Consecutive patients admitted with the following diagnoses from four different ethnic groups (Hispanic, African American, Asian, and Caucasian):
  • Preterm labor with intact membranes and with
  • acute inflammation;
  • chronic villitis;
  • vascular pathology;
  • no identifiable lesions.
  • Preterm delivery without labor because of the following reasons:
  • pre-eclampsia;
  • abruptio placentae;
  • fetal anomalies;
  • Other complications (e.g. automobile accidents) that necessitate immediate delivery.
  • PROM leading to preterm delivery and with
  • acute inflammation;
  • chronic villitis;
  • vascular pathology;
  • no identifiable lesions.
  • Term delivery without labor and no identifiable lesions.
  • Term delivery in spontaneous labor and no identifiable lesions.
  • Term delivery with chorioamnionitis.
  • Term delivery with failed labor leading to ceasarean section.
  • EXCLUSION CRITERIA:
  • Refusal of written informed consent
  • Fetal or maternal conditions mandating immediate delivery (i.e. fetal distress, significant hemorrhage, etc.)

Exclusion

    Key Trial Info

    Start Date :

    December 21 1999

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ACTUAL

    End Date :

    May 5 2016

    Estimated Enrollment :

    6838 Patients enrolled

    Trial Details

    Trial ID

    NCT00342277

    Start Date

    December 21 1999

    End Date

    May 5 2016

    Last Update

    February 24 2023

    Active Locations (4)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 1 (4 locations)

    1

    Wayne State University

    Detroit, Michigan, United States, 48201

    2

    Sotero del Rio Hospital

    Puente Alto, Chile

    3

    Padova Hospital

    Padua, Italy

    4

    Seoul National University

    Seoul, South Korea