Status:
COMPLETED
Genetics of Familial Testicular Cancer
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Testicular Cancer
Eligibility:
MALE
4-100 years
Brief Summary
This study is a collaboration between the Clinical Genetics Branch of the National Cancer Institute and the International Testicular Cancer Linkage Consortium (ITCLC). The primary goal of the ITCLC is...
Detailed Description
Familial clustering of testicular germ cell tumors (TGCT) is well-documented, and a family history of TGCT is associated with an increased risk of this disease. The International Testicular Cancer Lin...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- The criterion establishing familial TGCT is the presence of at least two cases of documented GCT in blood relatives.
- A case will be determined to have TGCT according to the following criteria:
- Pathologic confirmation of a germ cell-derived tumor arising in the testis. Estragonadal sperm cell tumors will also be included.
- Germ cell-derived histologies including: seminoma, embryonal carcinoma, endodermal sinus (yolk sac) tumor, gonadoblastoma, choriocarcinoma, teratoma, and mixed germ cell tumor.
- A case will be determined to have TIN on the basis of pathologic confirmation of intratubular malignant germ cells (ITMGCs) as defined by Burke and Mostofi.
Exclusion
Key Trial Info
Start Date :
January 2 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 14 2020
Estimated Enrollment :
1842 Patients enrolled
Trial Details
Trial ID
NCT00342537
Start Date
January 2 2004
End Date
July 14 2020
Last Update
July 17 2020
Active Locations (1)
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1
National Cancer Institute (NCI), 9000 Rockville Pike
Bethesda, Maryland, United States, 20892