Status:
COMPLETED
New Techniques for Using a Saline Wash as a Diagnostic Tool for Pneumocystis Pneumonia
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsors:
National Institutes of Health Clinical Center (CC)
Conditions:
Pneumocystis Infection
Infection
Eligibility:
All Genders
3-99 years
Brief Summary
This study will examine the effectiveness of a new laboratory method for detecting pneumocystis organisms in a salt-water (saline) oral wash. Pneumocystis infection in people with weakened immunity es...
Detailed Description
This study is designed to collect respiratory secretion specimens and blood samples to facilitate studies of human Pneumocystis infection and disease, to detect genes associated with drug resistance, ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Either:
- A. Patients (male or female) who are immunosuppressed with acute pneumonia and are undergoing or have undergone a clinically indicated procedure, such as bronchoscopy or sputum induction, to obtain a respiratory sample for diagnostic purposes.
- or
- B. Patients (male or female) who are immunosuppressed with acute pneumonia or individuals likely to be exposed to environmental or person-to-person sources of organisms, including healthy volunteers (with or without respiratory disease), health care professionals, patient families, or other patients in health care facilities who are willing to provide oral washes, nasal samples or blood samples and to consider providing an induced sputum sample.
- All ages greater than or equal to 3 years.
- Ability of individual or guardian to give informed consent.
- EXCLUSION CRITERIA:
- For enrollment under category B, any individual who cannot safely provide an oral wash or nasal samples (nasopharyngeal swabs, or nasal washes) as determined by the health care provider.
- Pregnancy and age are not exclusion factors.
- Nasal specimens will not be collected from children.
Exclusion
Key Trial Info
Start Date :
September 28 1999
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
1015 Patients enrolled
Trial Details
Trial ID
NCT00342589
Start Date
September 28 1999
Last Update
January 8 2026
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892