Status:
UNKNOWN
Noninvasive Positive Pressure Ventilation for ALI/ARDS:a Multicentre Randomized Controlled Trial
Lead Sponsor:
Beijing Chao Yang Hospital
Conditions:
Acute Lung Injury
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
with appropriate inspired oxygen concentrations, NPPV would prevent intubation and hence avert the poor outcome associated with the need of invasive ventilation in patients with ALI/ARDS.
Detailed Description
Noninvasive positive-pressure ventilation (NPPV) is increasingly being used in the care of patients suffering acute respiratory failure. High-level evidence supports the use of NPPV to treat exacerbat...
Eligibility Criteria
Inclusion
- Meet the ALI/ARDS criteria
Exclusion
- Age \> 85
- pH \< 7.35 or PaCO2 \>50mmHg
- Glasgow Coma Scale (GCS)\<11
- Airway or facial deformity
- Pneumothorax or pneumomediastinum
- Unable to spontaneously clear secretions from their airway
- Respiratory arrest
- Shock or hemodynamic instability (systolic blood pressure \<90 mmHg associated with decreased urinary output (\<20 mL.h-1) despite fluid repletion and use of vasoactive agents) of other causes
- Severe ventricular arrhythmia or active myocardial ischemia
- Severe organ dysfunction (including gastrointestinal hemorrhage, disseminated intravascular coagulation, hepatic and renal dysfunction, SOFA score\>1)
- End-stage patients who are expected to survive less than six months
- Severe abdominal distension
- Refuse to receive NPPV
- Unable to cooperate with the application of NPPV
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
End Date :
December 1 2007
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00343993
Start Date
June 1 2006
End Date
December 1 2007
Last Update
April 4 2007
Active Locations (1)
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1
Beijing chaoyang hospital-affiliate of capital medical university
Beijing, China, 100020