Status:
COMPLETED
Changes in HIV Viral Load in Patients Undergoing Treatment for Filariasis
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Filarial Infection
HIV Infections
Eligibility:
All Genders
18+ years
Brief Summary
This study, sponsored by the National Institutes of Health and the Tuberculosis Research Centre and YRG-Care in Chennai, India, will examine how treatment of lymphatic filariasis in HIV-infected patie...
Detailed Description
To determine the effect of pre-existing filarial infection and its treatment on viral burden and clinical parameters in patients infected with HIV, this study aims to follow plasma HIV loads, CD4 coun...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Greater than 18 years of age.
- Ability to give informed consent
- HIV positive
- If on antiretrovirals or treatment for opportunistic infections, have it be a stable maintenance period of at least 2 months
- Male or female, providing women are neither pregnant nor breast-feeding
- Willingness to adhere to the testing schedule of the protocol and to provide small amounts of blood (5 ml) on multiple occasions
- Willingness to be treated with DEC/albendazole
- Willingness, if female, to be tested for pregnancy and to be informed of the test result
- Willingness to have samples stored for future research
- EXCLUSION CRITERIA:
- Acutely ill at the time of enrollment into the study i.e. newly diagnosed with an opportunistic infection and not yet stabilized on a treatment regime.
- Hemoglobin less than 9 g/l for women and less than 10 g/l for men
- AST, ALT greater than 5 times normal
- Evidence of acute HIV infection (acute antiretroviral syndrome)
- Active tuberculosis or known tuberculosis
- A true allergy to DEC or albendazole
- At the discretion of the investigator if it is felt that someone is not appropriate for the study (i.e. known active drug use, patient with history of chronic noncompliance in clinic visits)
Exclusion
Key Trial Info
Start Date :
August 8 2005
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2012
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT00344279
Start Date
August 8 2005
End Date
January 31 2012
Last Update
July 2 2017
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Government General Hospital
Chennai, India
2
Tuberculosis Research Centre
Chennai, India
3
YRG Care
Chennai, India