Status:
WITHDRAWN
Transplantation of Tissue Cultured Human Amniotic Epithelial Cells Onto Damaged Ocular Surfaces
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Corneal Epithelial Dystrophy
Eligibility:
FEMALE
18-88 years
Phase:
NA
Brief Summary
To investigate the effect of using tissue cultured human amniotic epithelial cells to re-establish severely damaged ocular surfaces. Specifically, to determine the efficacy of transplanted tissue cult...
Detailed Description
Ocular surface diseases and injury caused by chemicals, result in chronic ulceration, and may never be able to be healed normally, and may lead to permanent vision loss. Standard medical treatments of...
Eligibility Criteria
Inclusion
- Patients with corneal epithelial defects and ulcers that have persisted for 4 weeks or longer, regardless of their cause. These patients will have received traditional medical therapy, including correcting the underlying causes, suppressing inflammation, and augmenting the tissue healing processes, but the epithelial defects have persisted.
Exclusion
- Patients who are pregnant or under age 18 will be excluded.
- Placentas will not be used if the following problems are present:
- If the mother has an infection at the time of her baby's birth;
- If the mother has a high risk of developing infection due to intravenous drug use or other factors;
- If the mother has diabetes, arthritis, or raised blood pressure;
- If the baby is unhealthy;
- If there is evidence of infection of the womb (uterus) and afterbirth (placenta) at the time of delivery.
Key Trial Info
Start Date :
September 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00344708
Start Date
September 1 2000
End Date
April 1 2010
Last Update
August 22 2018
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Aston Ambulatory Care Center
Dallas, Texas, United States, 75390-8866
2
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75390-8866