Status:
COMPLETED
Effects of Acute L-NMMA Treatment on Renal Hemodynamics and Vasoactive Hormones in Patients With Congestive Heart Failure
Lead Sponsor:
Regional Hospital Holstebro
Conditions:
Congestive Heart Failure
Eligibility:
All Genders
20-75 years
Phase:
PHASE1
Brief Summary
The study tests the hypothesis that nitric oxide availability is changed in congestive heart failure with regard to the regulation of renal hemodynamics, renal sodium excretion and release of vasoacti...
Detailed Description
The purpose of the study is to investigate the effects of systemic treatment with Ng-monomethyl-l-arginine in congestive heart failure and healthy controls on: * glomerular filtration rate and renal ...
Eligibility Criteria
Inclusion
- Healthy controls
- Age 20 to 60 years
- Both men and women
- Weight below 100 kg
- Normal clinical examination and laboratory screening
- Fertile women only if using contraception
- Informed consent according to the regulations of the local ethics committee
- Heart failure
- Both men and women
- Age 20 to 75 years
- Patients with heart failure in NYHA group II-III. Heart failure must be derived from ischaemic heart disease or dilated cardiomyopathy. Diagnosis must be verified by history and echocardiography or isotope cardiography.
- ejection fraction \< 0.40
- P-creatinin \< 250 µmol/L
- Fertile women only if using contraception
- Informed consent according to the regulations of the local ethics committee
Exclusion
- Healthy controls
- History or clinical evidence of diseases of the heart and blood vessels, kidneys, liver and pancreas, endocrine organs, lungs, neoplastic disease, myocardial infarction or cerebrovascular insult as evaluated by clinical examination and laboratory screening
- Current medication
- Drugs or alcohol abuse
- Pregnancy
- Previously within one year received more than 0.2 mSV radioactive treatment or diagnostic substances
- Donation of blood less than 1 month before the experiments
- Heart failure
- Cardiac valvular disease with stenosis
- Significant cardiac arrythmia
- Myocardial infarction, PTCA or by-pass surgery less than 3 months before the study
- Diseases of the lever, kidneys, lungs or endocrine organs which are not secondary to congestive heart failure
- Arterial hypertension
- Neoplastic disease
- Cerebrovascular insult
- Treatment with ACE-inhibitors or nitrates which cannot be stopped 1 week before study
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00344734
Last Update
June 27 2006
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