Status:
COMPLETED
Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls
Lead Sponsor:
Regional Hospital Holstebro
Conditions:
Hypertension
Eligibility:
All Genders
20-60 years
Phase:
PHASE1
Brief Summary
The study tests the hypothesis that systemic and renal nitric oxide synthesis is changed in essential hypertension by investigating the effects of a non selective nitric oxide inhibitor on renal hemod...
Detailed Description
The study investigates the effects of Ng-monomethyl-L-arginine (L-NMMA) on: 1. renal hemodynamics (renal plasma flow and glomerular filtration rate) 2. renal sodium excretion 3. lithium clearance and...
Eligibility Criteria
Inclusion
- Essential hypertension (blood pressure \> 140/90) with no signs of secondary hypertension
- P-creatinine \< 200 µmol/L
Exclusion
- Anamnestic or clinical signs of heart disease, renal disease, liver disease, neoplastic disease, anemia or cerebro-vascular insult
- Medication except antihypertensives
- Drug or alcohol abuse
- Pregnancy
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00345150
Last Update
June 27 2006
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