Status:
COMPLETED
An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa
Lead Sponsor:
New York State Psychiatric Institute
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Eating Disorders
Eligibility:
FEMALE
12-17 years
Brief Summary
The aim of this project is to use both multimodal MRI and behavioral measures to investigate how changes in frontostriatal neural systems contribute to the development and persistence of Bulimia Nervo...
Detailed Description
Patients with Bulimia Nervosa (BN) have difficulty regulating impulsive behaviors as suggested by their binge-eating and purging, as well as the high incidence of drug abuse and shoplifting in this po...
Eligibility Criteria
Inclusion
- Current or prior DSM IV diagnosis of Bulimia Nervosa or Sub-threshold Bulimia Nervosa (those who meet all DSM-IV criteria for BN, but engage in subjective binge-eating episodes and binge/purge at a frequency of at least once per week for 3 months, whereas meeting full DSM-IV criteria for BN requires binge eating and purging twice per week for 3 months)
- Major Depression
- For control adolescents, no current or past history of an eating disorder
Exclusion
- Ferromagnetic implants (e.g., pacemaker)
- Metal braces or retainers
- IQ less than 80
- Any other current major Axis I disorder, other than major depressive disorder (MDD)
- History of concussion, seizure disorder, or other neurological illness
- Claustrophobia
- Pregnant
Key Trial Info
Start Date :
October 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2021
Estimated Enrollment :
71 Patients enrolled
Trial Details
Trial ID
NCT00345943
Start Date
October 1 2004
End Date
August 1 2021
Last Update
December 2 2021
Active Locations (1)
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1
New York State Psychiatric Institute at Columbia University Medical Center
New York, New York, United States, 10032