Status:
COMPLETED
Health Effects From Removal of Amalgam Restorations in Patients With Symptoms Allegedly Related to Dental Amalgam
Lead Sponsor:
University of Bergen
Collaborating Sponsors:
NORCE Norwegian Research Centre AS
Conditions:
Adverse Effects
Dental Restoration, Permanent
Eligibility:
All Genders
25-55 years
Phase:
PHASE4
Brief Summary
The aim of the project is to study changes in symptom load after removal of all dental amalgam restorations in patients with symptoms allegedly related to amalgam.
Detailed Description
Patients referred from dentists and physicians in the period 1993 to 1999 to the Dental Biomaterials Adverse Reaction Unit, Department of Health, UNIFOB AS, for symptoms related to amalgam restoration...
Eligibility Criteria
Inclusion
- Referred for examination of general health complaints related to amalgam
- Health complaints from at least three different organ systems
- Dental amalgam restorations present
- Data available on concentration of mercury in blood and urine at the initial examination
- Patient agreed to be contacted after the examination
Exclusion
- Serious disease (incl. severe allergy to foodstuff and severe rheumatoid arthritis)
- Mental instability or psychiatric disease
- Cases with complicated dental rehabilitation (incl. bridge prostheses)
- Allergy to dental replacement materials
- Severe periodontitis
- High caries activity
Key Trial Info
Start Date :
September 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00346944
Start Date
September 1 2002
End Date
March 1 2010
Last Update
August 28 2012
Active Locations (1)
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1
UNIFOB AS, Dental Biomaterials Adverse Reaction Unit
Bergen, Norway, NO-5009