Status:
COMPLETED
A Study of Avastin (Bevacizumab) in Combination With XELOX or FOLFOX-4 in Patients With Metastatic Colorectal Cancer.
Lead Sponsor:
Hoffmann-La Roche
Conditions:
Colorectal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This 2 arm study will compare the pharmacokinetics and safety of Avastin at steady state under 2 different dosing regimens, in combination with XELOX (oxaliplatin + Xeloda) or FOLFOX-4 (oxaliplatin, l...
Eligibility Criteria
Inclusion
- adult patients, \>=18 years of age;
- adenocarcinoma of the colon or rectum, with metastatic or locally advanced disease;
- \>=1 target lesion.
Exclusion
- patients who have previously received systemic treatment for advanced or metastatic disease;
- patients who have received adjuvant treatment for non-metastatic disease in past 3 months;
- previous therapy with oxaliplatin or Avastin.
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2008
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT00349336
Start Date
August 1 2006
End Date
November 1 2008
Last Update
September 18 2012
Active Locations (7)
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1
Box Hill, Australia, 3128
2
Fitzroy, Australia, 3065
3
Sydney, Australia, 2031
4
Brampton, Ontario, Canada, L6R 3J7