Status:
COMPLETED
Effect of Glucose on Ocular Blood Flow
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Coronary Vasospasm
Eligibility:
All Genders
18-85 years
Brief Summary
The primary objective is to assess the effect of glucose on retinal vascular diameter in otherwise healthy vasospastic subjects compared to non-vasospastic controls. The secondary objective is to com...
Detailed Description
It is known that a glucose load can induce an increase in ocular blood flow. Acute hyperglycemia increases retinal vessel diameters in animals and humans. The purpose of this study is to compare the e...
Eligibility Criteria
Inclusion
- No history of the following problems: ocular or systemic disease; chronic or current systemic or topical medication; or of drug or alcohol abuse
- normal blood pressure (100-140 / 60-90 mmhg)
- best corrected visual acuity above 20/25 in both eyes
- no pathological findings upon a slit-lamp examination and indirect fundoscopy
- ametropia within -3 to +3 diopters of spherical equivalent
- less than 1 diopter astigmatism
- IOP \< 20 mmHg in both eyes
- Subjects will be classified as vasospastic if they relate a clear history of frequent cold hands (answering yes to the questions: "do you have always cold hands, even during summer time?" and "do other people tell you that you have cold hands?") and as normals if they deny such a history
- Vasospastic propensity will also be assessed by capillaroscopy
Exclusion
- Subjects describing "sometimes cold hands"
- if the test substance cannot be ingested
- not obtainable ocular blood flow measurements
- abnormally high levels of glucose at any point in time
Key Trial Info
Start Date :
December 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2003
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00350129
Start Date
December 1 2002
End Date
February 1 2003
Last Update
March 19 2024
Active Locations (1)
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1
University Hospital Basel, Eye Clinic
Basel, Canton of Basel-City, Switzerland, 4031