Status:
COMPLETED
Masked Faces in Parkinson Disease: Mechanism and Treatment
Lead Sponsor:
University of Florida
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Parkinson's Disease
Eligibility:
All Genders
45-80 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to examine the effectiveness of high intensity respiratory muscle strength training in treating blunted facial expression in people with Parkinson disease.
Detailed Description
Facial expressions are complex signals that last only a few minutes and are important for communicating intention, motivation, and emotional states. In humans, a variety of neurological and psychiatri...
Eligibility Criteria
Inclusion
- A clinical diagnosis of idiopathic Parkinson disease
- Hoeh-Yahr Stage 1-3 when off medication
- Stable and optimal medical regimen for at least 3 months
- No previous surgical interventions for Parkinson's disease (i.e., deep brain stimulation, pallidotomy, stem cell implantation)
- Participants will include men and women between the ages of 45 and 80 years
Exclusion
- Evidence of dementia based on neurocognitive testing
- Current or past history of major psychiatric disturbance (e.g., schizophrenia, bipolar disorder, substance abuse). Participants who are taking anti-depressants will not be excluded as long as they are not currently depressed (Beck Depression, SCID)
- Other neurologic disturbance (e.g., tumor, stroke, traumatic brain injury, epilepsy) or severe chronic medical illness (e.g., HIV, metastatic cancer)
- Presence of oro-facial dyskinesias
- Previous surgeries to the larynx that result in poor vocal fold closure and/or positive history of head and neck cancer
- History of smoking in the past 5 years
- Untreated hypertension
- Failing a baseline test of pulmonary function during baseline respiratory evaluation
- Known respiratory complications such as chronic obstructive pulmonary disease (POCD), asthma
- Previous surgical interventions for Parkinson's disease (i.e., deep brain stimulation, pallidotomy, stem cell implantation)
Key Trial Info
Start Date :
December 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT00350402
Start Date
December 1 2004
End Date
November 1 2009
Last Update
April 6 2012
Active Locations (1)
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1
Cognitive Neuroscience Laboratory, L3-135, McKnight Brain Institute, University of Florida
Gainesville, Florida, United States, 32601