Status:
COMPLETED
St. John's Wort in the Treatment of Raynaud's Phenomenon
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Raynaud's Disease
Eligibility:
All Genders
16-70 years
Phase:
PHASE3
Brief Summary
This trial will test the efficacy of St. John's Wort (SJW) as a supplement, in the treatment of Raynaud's phenomenon (RP). The investigators are hypothesizing that taking SJW 300mg, 3 times a day will...
Detailed Description
Raynaud's Phenomenon (RP) is a common vasospastic problem of digital artery vessels causing pain and ischemic fingers (the fingers turn white and then blue and or red). It is considered primary when i...
Eligibility Criteria
Inclusion
- Males or Females between 16 and 70 years old
- Primary or secondary Raynaud's phenomenon, as diagnosed by a rheumatologist
- Clinical need for treatment of Raynaud's phenomenon
- Experiences at least 7 attacks per week
- Willing and able to provide informed consent
Exclusion
- Prior allergic reaction to St. John's Wort
- Pregnancy or possibility or pregnancy in the next 4 months
- Women that are currently breastfeeding
- Depression requiring treatment
- Use of SSRIs or other antidepressants with the exception of low dose amitriptyline used for reasons other than depression
- Use of drugs that are potentiated by St. John's Wort, such as cyclosporine, coumadin, digoxin, and theophylline. The complete list of contraindicated medications can be received from investigator
- Clinically significant non-compliance with past therapies
- Anticipated need for surgery (sympathectomy) in the next three months
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00351117
Start Date
March 1 2007
End Date
August 1 2008
Last Update
July 14 2009
Active Locations (1)
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1
Rheumatology Clinic, St. Joseph's Health Care
London, Ontario, Canada, N6A 4V2