Status:
COMPLETED
Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria
Lead Sponsor:
University of South Florida
Collaborating Sponsors:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Arthritis, Reactive
Reiter Disease
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
Reactive arthritis, also known as Reiter's syndrome, is a form of arthritis that occurs as a reaction to an infection elsewhere in the body. It is characterized by inflammation of the joints, tendons,...
Detailed Description
The initial infection that causes reactive arthritis is caused by one of two bacteria: Chlamydia trachomatis, which is usually acquired through sexual contact, or Chlamydia pneumoniae, which can cause...
Eligibility Criteria
Inclusion
- Meet the following European Spondyloarthropathy Study Group Criteria:
- inflammatory spinal pain OR
- synovitis AND
- one or more of the following:
- positive family history
- urethritis or cervicitis within 1 month prior to onset of arthritis
- buttock pain
- enthesopathy
- sacroiliitis
- Disease duration of at least 6 months
- Negative pregnancy test at study baseline and willing to use an effective method of contraception other than combined oral contraceptives for the duration of the study (for women of childbearing age)
Exclusion
- Sensitivity or history of allergic reaction to rifampin, doxycycline, or azithromycin
- Currently taking any medications that may interact with the study medications, specifically rifampin
- Liver transaminases greater than or equal to two times the normal level
- Significant abnormalities in the complete blood count (CBC)
- Pregnant
- Current psoriasis
- Diagnosis of inflammatory bowel disease
- Diagnosis of ankylosing spondylitis
- Previous prolonged exposure to antibiotics (more than 2 weeks) as a potential treatment for reactive arthritis
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT00351273
Start Date
May 1 2006
End Date
September 1 2008
Last Update
November 13 2018
Active Locations (3)
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1
University of South Florida
Tampa, Florida, United States, 33612
2
Louisiana State University
New Orleans, Louisiana, United States, 70112
3
University of Toronto
Toronto, Ontario, Canada, M5T 2S8