Status:
COMPLETED
Evaluation of an Algorithm for Intensive s.c. Insulin Therapy in Emergency Room Patients With Hyperglycaemia
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Hyperglycemias
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of this study is to test the safety and efficacy of a new algorithm for intensive s.c. insulin injection in medical emergency patients with hyperglycaemia (plasma glucose concentration ≥ 8 mmo...
Detailed Description
BACKGROUND: Prospective randomized trials have shown that near-normoglycemic blood glucose control using insulin infusions achieves a significant reduction in mortality of severely ill patients in int...
Eligibility Criteria
Inclusion
- all patients with hyperglycaemia (≥ 8.0 mmol/l) admitted to the medical emergency room.
- patients with presumed hospitalisation in ER or medical ward of more than 48 h duration.
Exclusion
- patients in shock (defined as hypotension or shock index \> 1 with oliguria, changed mental status and metabolic acidosis)
- patients with a terminal illness on palliative care
- patients with type 1 diabetes
- patients with insulin pump therapy
- patients with need for hospitalisation in the intensive or coronary care unit.
- patients with presumed hospitalisation shorter than 48 hours
- known pregnancy (in women with childbearing potential pregnancy test for exclusion mandatory)
- no informed consent
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT00353431
Start Date
December 1 2006
End Date
October 1 2010
Last Update
May 18 2012
Active Locations (1)
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1
Division of Endocrinology, Diabetes & Clinical Nutrition, Dept of Internal Medicine,
Basel, Canton of Basel-City, Switzerland, 4031