Status:
COMPLETED
Telomere Repair Gene Mutation in Inflammatory Bowel Disease
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Inflammatory Bowel Disease
Eligibility:
All Genders
2-80 years
Brief Summary
This study will evaluate and compare the genes of the telomere repair complex in healthy control subjects, patients with blood diseases, and patients with inflammatory bowel disease to identify what, ...
Detailed Description
We have identified inherited mutations in genes of the telomere repair complex in patients with acquired aplastic anemia. These mutations diminish the ability of cells to repair the ends of chromosome...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Diagnosis of ulcerative colitis or regional enteritis
- For adults:
- Ability to comprehend the investigational nature of the study and provide informed consent. Or
- For minors: Written informed consent from one parent or guardian and informed assent. The process will be explained to the minor on a level of complexity appropriate for their age and ability to comprehend.
- Age greater than 2 but less or equal to 80 years old
- EXCLUSION CRITERIA:
- All subjects not fulfilling the inclusion criteria will be considered ineligible.
Exclusion
Key Trial Info
Start Date :
May 15 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 21 2020
Estimated Enrollment :
95 Patients enrolled
Trial Details
Trial ID
NCT00353639
Start Date
May 15 2006
End Date
May 21 2020
Last Update
May 22 2020
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892