Status:
COMPLETED
Identification of Genes Expressed in Atherosclerotic Plaque
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Atherosclerosis
Eligibility:
All Genders
21-100 years
Brief Summary
This study will identify genes and proteins in the blood of patients with atherosclerosis and in that of normal volunteers. The findings will be compared to determine the influence of these substances...
Detailed Description
Significant progress has been made in the prevention and treatment of atherosclerosis, but it continues to be a leading cause of morbidity and mortality in our society. The problem will become even mo...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Any adult patient with carotid artery disease or known atherosclerosis capable of giving informed consent.
- INCLUSION CRITERIA FOR MEDICATION TREATED SUBJECT:
- Any adult with normal total cholesterol (less than 200 mg/dl) and blood pressure (systolic less than 140 and diastolic less than 90).
- INCLUSION CRITERIA FOR NORMAL BRONCHOSCOPY SUBJECT:
- Any healthy adult subject with no history of peripheral or coronary artery disease, who is eligible for bronchoalveolar lavage per Protocol 99-H-0068 and capable of giving informed consent.
- EXCLUSION CRITERIA:
- Unable to give consent
- History of chronic infections, vasculitis or any other inflammatory disease
- History of neoplastic disease or chemotherapy treatment
- Immunosuppressive medications other than common over-the-counter drugs such as aspirin or acetaminophen
- EXCLUSION CRITERIA FOR MEDICATION TREATED SUBJECT:
- Subject with abnormal liver and renal function tests on pretreatment screening or currently taking a statin or ACE inhibitor medication.
- EXCLUSION CRITERIA FOR NORMAL BRONCHOSCOPY SUBJECT:
- Any exclusion criteria for normal subject listed in Protocol 99-H-0068.
Exclusion
Key Trial Info
Start Date :
October 21 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 12 2011
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT00353730
Start Date
October 21 2002
End Date
January 12 2011
Last Update
September 8 2021
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Suburban Hospital
Bethesda, Maryland, United States, 20814
2
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892