Status:
COMPLETED
Genetic Analysis of African-Americans With High Blood Pressure
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Hypertension
Eligibility:
All Genders
21+ years
Brief Summary
The purpose of this study is to learn if kinase, a protein found in the heart, contributes to thickening of the heart muscle in people with high blood pressure. A protein called myosin causes the hea...
Detailed Description
Genetic and in vitro mechanical studies in our laboratory have suggested that the perturbations in the phosphorylation of the cardiac myosin regulatory light chain (RLC) can modulate cardiac function ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Inclusion Criteria (Main Cohort):
- Afro-American patients with a history of hypertension
- Age greater than or equal to 21 years old
- Presence of the kinase allele (homo or heterozygous)
- Ability to give informed consent.
- Inclusion Criteria (Myopathy Cohort):
- All of the above as well as:
- Left ventricular ejection fraction of less than 35% by any imaging technique.
- EXCLUSION CRITERIA
- For subjects with Kinase Allele:
- There will be no exclusion criteria. Patients will be evaluated even if they are only able to participate in part of the study.
- For Subjects without the kinase allele and Myopathy Cohort:
- History of myocardial infarction
- History of significant valve disease
- History of primary hyperthropic or infiltrative cardiomyopathy
- History of rheumatic heart disease
- Chronic atrial arrhythmia, bundle branch block intraventricular conduction defect or definite myocardial infarction on EKG
- Inability to perform a metabolic stress test
- Inability to perform a cMRI
- Poor echocardiographic windows precluding accurate analysis
Exclusion
Key Trial Info
Start Date :
October 5 1999
Trial Type :
OBSERVATIONAL
End Date :
December 10 2007
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT00353925
Start Date
October 5 1999
End Date
December 10 2007
Last Update
July 2 2017
Active Locations (1)
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1
University of Maryland, Baltimore
Baltimore, Maryland, United States, 21201-1595