Status:
COMPLETED
Comparison of Long- and Short-acting Diuretics in Congestive Heart Failure
Lead Sponsor:
Hyogo Medical University
Collaborating Sponsors:
Ministry of Health, Labour and Welfare, Japan
Conditions:
Congestive Heart Failure
Eligibility:
All Genders
20+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare therapeutic effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting one, in patients with heart failure, and to test our hypothesis th...
Detailed Description
The mortality and morbidity of heart failure are still high despite emerging evidences that have shown beneficial effects of ACE inhibitor, beta-blocker, ARB, and aldosterone receptor antagonist. Diur...
Eligibility Criteria
Inclusion
- Clinical diagnosis of heart failure based on a slight modification of the Framingham criteria as previously described within 6 months before the entry
- Current status of heart failure is NYHA II or III.
- Currently, loop diuretic(s) is (are) administered.
- No change in baseline therapy and symptoms of heart failure within a month
Exclusion
- Current symptomatic hypotension
- Hypertension that has not been controlled to the satisfaction of the investigator
- Hemodynamically significant (in the investigators opinion) LV outflow tract obstruction (due to either aortic stenosis or ventricular hypertrophy)
- Acute coronary syndrome
- Primary pulmonary hypertension or pulmonary hypertension not due to LV dysfunction
- Serious cerebrovascular disease
- Acute myocardial infarction within the last 3 months
- Patients who require intravenous inotropes
- Cerebrovascular accident within the last 3 months
- Percutaneous coronary intervention or open heart surgery within the last 3 months
- On the waiting list for percutaneous coronary intervention or open heart surgery
- Serum creatinine \> 2.5 mg/dl
- Serious liver disease
- Any change in cardiovascular drug therapy within a month prior to randomization
- History of chronic obstructive pulmonary disease or restrictive lung disease
- Diabetes mellitus that has not been well controlled (fasting blood glucose\>200 mg/dl、HbA1c \> 8%)
- Any life-threatening acute disease
- Patients with implantable cardiac defibrillator
- Other diseases likely to cause death or serious disability during the period of the study
- Patients unable to walk without personal aid
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2010
Estimated Enrollment :
320 Patients enrolled
Trial Details
Trial ID
NCT00355667
Start Date
June 1 2006
End Date
August 1 2010
Last Update
August 18 2016
Active Locations (1)
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1
The Hospital of Hyogo College of Medicine
Nishinomiya, Hyōgo, Japan, 663-8501