Status:
TERMINATED
Alpha-Adrenoceptor Vascular Function In Chronic Kidney Disease Focus On The Role Of Endothelial Nitric Oxide
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Chronic Kidney Disease
Hypertension
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The purpose of this study is to learn more about why most patients with early stages of kidney disease have high blood pressure. We know the body produces natural substances that cause blood vessels ...
Detailed Description
Enhanced adrenergic vascular reactivity may significantly contribute to hypertension and the excessive cardiovascular disease burden in patients with chronic kidney disease (CKD). Nitric oxide (NO), a...
Eligibility Criteria
Inclusion
- Men and Women-18 to 55 years of age.
- There are three groups of volunteers.
- Group A. People who are hypertensive with kidney disease. When not taking blood pressure medicines, blood pressure must have a systolic between 140-170 mmHg. Diastolic must be between 90-109 mmHg.Kidney function should be around half of normal. Urine protein must be no more than 1 gram in a 24-hour urine time period.
- Group B. People who are hypertensive without kidney disease. Blood pressure must have a systolic between 140-170 mmHg. Diastolic must be between 90-109 mmHg. Kidney function should be normal. Normal amounts of protein in their urine.
- Group C. People who are normotensive. Blood pressure must have a systolic below 131/mmHg. Diastolic must be below 81 mmHg. Kidney function should be normal. No more than normal amounts of protein in their urine.
Exclusion
- People with:
- Diabetes
- Lung disease
- Stomach disease
- Liver disease
- Blood vessel disease
- Heart disease
- Hereditary blood disorders
- Hematocrit (amount of red blood cells) less than 30%
- Current tobacco use
- Kidney disease who require dialysis
- Women who are pregnant or breastfeeding
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2010
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00356265
Start Date
July 1 2006
End Date
November 1 2010
Last Update
January 23 2018
Active Locations (1)
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1
University of Michigan Hospital
Ann Arbor, Michigan, United States, 48109