Status:
COMPLETED
Inflammatory Response During Anesthesia and Surgery
Lead Sponsor:
UMC Utrecht
Collaborating Sponsors:
European Association of Cardiothoracic Anaesthesiologists
Conditions:
Systemic Inflammatory Response Syndrome
Myocardial Ischemia
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to investigate the effects of total intravenous anesthesia versus volatile anesthesia on the perioperative inflammatory response during and after major surgery.
Detailed Description
Patients undergoing major surgical procedures, in particular those undergoing cardiac surgery, develop a severe inflammatory response in up to 50% of cases leading to increased mortality and morbidity...
Eligibility Criteria
Inclusion
- Patients older than 18 years and planned for elective Coronary Artery Bypass Grafting (CABG), aorta surgery or Implantable Cardioverter Defibrillator (ICD) replacement
Exclusion
- Emergency operations
- Patients undergoing combined or re-do procedures
- Patients who are diagnosed with or undergoing treatment for a steroid or hormone disorder, excluding diabetes
- Patients suffering from chronic inflammatory diseases
- Patients suffering form current infections
- Patients currently treated with steroids
- Patients undergoing treatment or care for a malignancy
- Patients participating in another study that may interfere with the endpoints of the IRAS trial
Key Trial Info
Start Date :
March 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00356746
Start Date
March 1 2006
End Date
March 1 2009
Last Update
June 24 2015
Active Locations (1)
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1
UMC Utrecht, Division of Perioperative Care and Emergency Medicine, Department of Anesthesiology
Utrecht, Netherlands, 3508 GA