Status:
COMPLETED
Role of Brain Region Changes in Tactile (Touch) Ability Following Nerve Block
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Tactile Spatial Acuity
Healthy
Eligibility:
All Genders
18+ years
Brief Summary
This study will examine the role of different brain regions in tactile (touch) ability after application of a tourniquet (inflated blood pressure cuff). When the forearm is deprived of blood for a sho...
Detailed Description
Acute deafferentation in one hand leads to improvements in tactile discriminative skills in the other, non-deafferented hand. This phenomenon, recently identified in our laboratory, represents an adap...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Normal volunteers who are willing and able to remain relaxed and immobile during active scans, for a period of up to 2 hours.
- EXCLUSION CRITERIA:
- Subjects with: metal in the cranium except for crowns or fillings in mouth and permanent metal dental braces, metal fragments from occupational exposure or surgical clips in or near the brain.
- Subjects with eye, blood vessel, cochlear or eye implants, with increased intracranial pressure as evaluated by clinical means, with cardiac or neural pacemakers, intracardiac lines and/or implanted medication pumps.
- Subjects with large hemorrhagic or brain stem stroke.
- Subjects with multiple cerebral lesions with residual deficits.
- Subjects with history of head injury with loss of consciousness.
- Subjects with history of severe alcohol or drug abuse or psychiatric illness.
- Subjects with unstable cardiac dysrhythmia or unresponsive arterial hypertension (greater than 160/100 mmHg).
- Subjects with history of hyperthyroidism or individuals receiving drugs acting primarily on the central nervous system or disorders of the blood coagulation system.
- Subjects with excessive callus at their fingers.
- Preganant women will be excluded from the study.
- SUBJECTS DISCONTINUATION CRITERIA:
- Subject's poor compliance with protocol evaluations or examinations and subject's request to withdraw.
Exclusion
Key Trial Info
Start Date :
December 12 2001
Trial Type :
OBSERVATIONAL
End Date :
December 28 2007
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00357058
Start Date
December 12 2001
End Date
December 28 2007
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892