Status:
WITHDRAWN
Fetal Aortic Pulsewave Velocity: A Novel Doppler Ultrasound Method of Measuring the Biophysical Properties of the Fetal Aorta
Lead Sponsor:
University of British Columbia
Conditions:
Healthy
Eligibility:
FEMALE
Brief Summary
We are interested in determining if we can measure the blood flow in the descending aorta (large blood vessel in the abdomen) of healthy fetuses and fetuses with growth restriction. An increasing numb...
Detailed Description
Prospective subjects will be recruited through: 1. Recruitment posters placed in the DAP department at BCWH. A contact number for the research nurse will be included on the recruitment poster for int...
Eligibility Criteria
Inclusion
- Study Group N:
- Singleton pregnancy between 20 weeks 0 days and 36 weeks 0 days Normal obstetrical ultrasound in DAP at BCWH between 20-36 weeks GA
- Study Group IUGR:
- Singleton pregnancy between 20 weeks 0 days and 36 weeks 0 days Obstetrical ultrasound in DAP at BCWH between 20-36 weeks GA demonstrating IUGR (abdominal circumference AC \<10%) and one of: a)oligohydramnios (amniotic fluid index (AFI) \<5%) or b)abnormal umbilical artery (UA) Dopplers (absent or reversed end-diastolic flow)
Exclusion
- Study Group N:
- Gestational age \<20 weeks or ≥36 weeks Multiple pregnancy Any known or suspected fetal structural anomaly (including cardiac) Chromosomal abnormalities (on amniocentesis or CVS) Abnormalities in fetal growth (AC \<10%; AC \>90%) Abnormalities in amniotic fluid volume (AFI \<5% or \>95%) Maternal hypertensive disorder (during or prior to pregnancy) Illicit drug use during pregnancy (cocaine, heroin, methamphetamine) Maternal medical history of any chronic illness requiring medication (eg lupus, asthma, etc.) Abnormal maternal serum triple screen (AFP ≥2.5MoM, hCG \>3.0 MoM)
- Study Group IUGR:
- Gestational age \<20 weeks or ≥36 weeks Multiple pregnancy Any known or suspected fetal structural anomaly (including cardiac) Chromosomal abnormalities (on amniocentesis or CVS) Normal fetal growth with AC ≥10% Illicit drug use during pregnancy (cocaine, heroin, methamphetamine)
Key Trial Info
Start Date :
May 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00359034
Start Date
May 1 2006
End Date
May 1 2013
Last Update
February 6 2014
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