Status:
COMPLETED
Physical Activity and Breast Cancer Risk in Postmenopausal Women:the SHAPE Study
Lead Sponsor:
UMC Utrecht
Collaborating Sponsors:
National Institute for Public Health and the Environment (RIVM)
Dutch Cancer Society
Conditions:
Breast Cancer
Eligibility:
FEMALE
50-69 years
Phase:
PHASE3
Brief Summary
Purpose of the SHAPE study is to examine the effects of an 1-year exercise programme on endogenous hormone levels associated with breast cancer among sedentary postmenopausal women and whether a decre...
Detailed Description
Physical activity has been associated with a decreased risk for breast cancer. The biological mechanism(s) underlying the association between physical activity and breast cancer is not clear. Most pro...
Eligibility Criteria
Inclusion
- Women aged 50 -69 year
- \> 12 months since last menses
- Non-smokers (at least 12 months)
- Sedentary
- Knowledge of the Dutch language
- Agreement to be randomly assigned to either the exercise intervention or control group
- Informed consent to participate in all screening and study activities
Exclusion
- Use of hormone replacement or oral contraceptives in past 6 months
- Morbidly obese (BMI \> 40)
- BMI \< 22
- Currently on or planning to go on a strict diet
- Ever diagnosed with breast cancer
- Diagnosis of other types of cancer in the past 5 years
- Diabetes mellitus or other endocrine related diseases
- Disorders or diseases (locomotor, optical, neurological, mental) that might impede the participation in the exercise programme
- Alcohol or drug abuse
- Maintenance use of corticosteroids
- Use of beta blockers
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
End Date :
September 1 2006
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT00359060
Start Date
January 1 2005
End Date
September 1 2006
Last Update
October 13 2006
Active Locations (1)
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1
University Medical Center Utrecht, Julius Center
Utrecht, Netherlands, 3508 GA