Status:
TERMINATED
Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
Lead Sponsor:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Cardiac Surgical Procedures
Cardiopulmonary Bypass
Eligibility:
All Genders
16+ years
Phase:
PHASE2
Brief Summary
Excessive bleeding is common after cardiac surgery. This may result in patients receiving a blood transfusion or suffering the life-threatening complication of cardiac tamponade. Tamponade is when exc...
Detailed Description
Hypothesis: Patients undergoing repeat median sternotomy or requiring prolonged cardiopulmonary bypass (CPB) often develop a coagulopathy at the end of surgery. We propose sequestering plasma and pla...
Eligibility Criteria
Inclusion
- Adult patients undergoing cardiac surgery that involves:
- Repeat median sternotomy
- Mitral valve repair
- Double valve operations
- Combined valve and coronary surgery
- Anticipated prolonged cardiopulmonary bypass
Exclusion
- Pre-operative anaemia
- Pre-operative thrombocytopenia
- Unstable angina
- Anti-platelet therapy (e.g. aspirin, clopidogrel) within the previous 7 days
- Known or symptomatic cerebrovascular disease
- Known disorders of haemostasis
- Aprotinin sensitivity
- Pregnancy.
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00359398
Start Date
August 1 2006
End Date
July 1 2009
Last Update
April 14 2016
Active Locations (1)
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1
Royal Brompton Hospital
London, United Kingdom, SW3 6LY