Status:
TERMINATED
Study to Evaluate Eye Function in Patients Taking Linezolid for Six Weeks or Greater
Lead Sponsor:
Pfizer
Conditions:
Optic Nerve Diseases
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
To understand and characterize the effects of linezolid on the optic nerve by observing and following patients who have been treated with linezolid for six weeks or longer for the development of signs...
Detailed Description
Characterize Optic Side Effect
Eligibility Criteria
Inclusion
- Male and female subjects who are 18 years of age or older.
- Subjects in Treated Group:
- Subjects must have received linezolid 600 mg BID for six weeks or greater and be currently on drug (or have received linezolid within 7 days of baseline evaluation).
- Subjects who have current signs or symptoms compatible with linezolid toxicity (i.e. optic or peripheral neuropathy) may be enrolled in the study if they are on linezolid at time of baseline evaluation (or have received linezolid within 7 days of baseline evaluation).
- Linezolid may be discontinued at any time at the primary physician's discretion and remain on the study.
- Women of childbearing potential must use adequate contraception
- Subjects in Control Group:
- Subjects will have a diagnosis similar to patients in the treated group and similar important co-morbidities and epidemiologic factors if possible.
Exclusion
- Subject in Treated Group:
- Subjects with a known presence of optic or peripheral nerve damage due to another illness, condition or medication.
- Subjects with a pre-existing or a diagnosis at time of screening visit of an ophthalmologic condition that would adversely affect the study testing protocol (e.g. dense cataracts, macular degeneration, retinitis pigmentosa).
- Subjects who are currently receiving or anticipated to receive another medication, antibiotic or other, that has known potential to produce ocular or neurologic toxicity indistinguishable from that caused by linezolid or lactic acidosis.
- Subjects with a history of significant exposure, in the opinion of the investigator and with prior discussion with the medical monitor, to medications known to produce optic or peripheral neuropathy.
- Subjects with an active communicable disease (i.e., tuberculosis assessed as currently communicable) and subjects on active treatment for tuberculosis or other mycobacterial disease that include drugs that have known potential to produce ocular or neurologic toxicity.
- Subjects with severe liver disease or abnormal liver function test.
- Subjects in Control Group:
- Subjects must not currently be taking linezolid or have received it for more than 7 days at any time.
- Subjects with a known presence of optic or peripheral nerve damage due to another illness, condition or medication.
- Subjects with a pre-existing or a diagnosis at the screening visit of an ophthalmologic condition that would adversely affect the study testing protocol (e.g. dense cataracts, macular degeneration, retinitis pigmentosa).
- Subjects who are currently receiving another medication, antibiotic or other, that has known potential to produce ocular or neurologic toxicity indistinguishable from that caused by linezolid or lactic acidosis.
- Subjects with a history of significant exposure, in the opinion of the investigator and with prior discussion with the medical monitor, to medications known to produce optic or peripheral neuropathy.
- Subjects with an active communicable disease (i.e., tuberculosis assessed as currently communicable) and subjects on active treatment for tuberculosis or other mycobacterial disease that include drugs that have known potential to produce ocular or neurologic toxicity.
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00359632
Start Date
November 1 2008
End Date
December 1 2013
Last Update
June 26 2015
Active Locations (12)
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1
St. Bernards Research Center
Jonesboro, Arkansas, United States, 72401
2
Triple O Research Institute, PA
West Palm Beach, Florida, United States, 33401
3
Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
4
Henry Ford Health System
Detroit, Michigan, United States, 48202