Status:
COMPLETED
Brain Imaging of Tinnitus
Lead Sponsor:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Hearing Disorder
Eligibility:
All Genders
30-65 years
Brief Summary
This study will use magnetic resonance imaging (MRI) to compare brain function in three groups of people: hearing-impaired people with tinnitus; hearing-impaired people without tinnitus; and people wi...
Detailed Description
Subjective tinnitus, the false perception of sound in the absence of an acoustic stimulus, occurs frequently as a consequence of noise-induced deafness. The purpose of this study is to investigate the...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Plus Tinnitus Plus Hearing loss subjects.
- Adults, between the ages of 30 to 65 years.
- Are able to hear and perceive sounds used in the experiment in the range 250 Hz to 2 KHz and have high-frequency sensorineural hearing loss beginning no lower than 2 KHz.
- In good health and not currently taking certain medications regularly (e.g. antidepressants, antiseizure medications, antipsychotics, etc.).
- Experience tinnitus daily.
- Have had non-pulsatile tinnitus for at least 1 year.
- Have bilateral or bilateral with unilateral dominance tinnitus.
- Minus Tinnitus Plus Hearing loss subjects.
- Adults, between the ages of 30 to 65 years.
- Are able to hear and perceive sounds used in the experiment in the range 250 Hz to 2 KHz and have high-frequency sensorineural hearing loss beginning no lower than 2 KHz.
- In good health and not currently taking certain medications regularly (e.g. antidepressants, antiseizure medications, antipsychotics, etc.).
- Have never or rarely (i.e. transient episodes experienced by virtually everyone) experienced tinnitus.
- Minus Tinnitus Minus Hearing loss subjects or normal volunteers.
- Adults, between the ages of 30 to 65 years.
- Have normal hearing.
- In good health and not currently taking certain medications regularly (e.g. antidepressants, antiseizure medications, antipsychotics, etc.).
- EXCLUSION CRITERIA:
- Subjects who have pacemakers, aneurysm clips, metallic prostheses or shrapnel fragments.
- Subjects incapable of giving informed consent.
- Subjects with a positive pregnancy test.
- Children below the age of 18 years.
- Subjects with hyperacusis or misophonia (hyper-sensitivity to loud noises).
- Subjects with mood disturbances such as depression or anxiety.
- Subjects with a history of temporomandibular joint problems or who present symptoms of pain and tenderness of the temporomandibular joint on examination.
- Subjects may be excluded for the following reasons that may cause difficulty with interpretation of the imaging data:
- Subjects with mental or physical illnesses, other than tinnitus that may cause problems with participation in the study.
- Subjects with current uncontrolled hypertension, or significant past history of cardiovascular disease and diabetes melitus.
- Subjects with a history of head trauma with loss of consciousness, epilepsy, seizures, a history of chemotherapy (neurotoxic or ototoxic) and other medical conditions that may alter cerebral functioning.
- Subjects who are taking or have a history of taking recreational drugs or alcoholism.
- Subjects with unilateral or asymmetrical hearing loss who have not had (or cannot provide documentation of) comprehensive neuro-otologic workup will be excluded.
Exclusion
Key Trial Info
Start Date :
July 28 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 7 2016
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT00359931
Start Date
July 28 2006
End Date
March 7 2016
Last Update
October 6 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892