Status:
COMPLETED
Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation
Lead Sponsor:
University Hospital Freiburg
Conditions:
Secondary Hypothyroidism
Hypopituitarism
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether a body weight adjusted dose of thyroxin is superior to treatment guided by laboratory results of thyroxin hormones in patients with central hypothyroi...
Detailed Description
Backround: A normal thyroid function is critical for metabolism, well-being and cognitive function. It is now well accepted that primary subclinical hypothyroidism, characterized by normal circulating...
Eligibility Criteria
Inclusion
- hypopituitarism of at least 3 axes (TSH plus gonadotropin, somatotropin, corticotropin or ADH deficiency)
- termination of surgical or radiation treatment of pituitary tumors at least six month before study entry
- BMI of 20 - 39.9 kg/m2
- non-smoking status.
Exclusion
- history of cardiovascular or pulmonary diseases
- current thyroxin dosage \> 1.6 µg/kg bw
- pregnancy
- epilepsy
- cerebrovascular diseases
- nodular goiter
Key Trial Info
Start Date :
February 1 2004
Trial Type :
INTERVENTIONAL
End Date :
April 1 2007
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00360074
Start Date
February 1 2004
End Date
April 1 2007
Last Update
June 9 2008
Active Locations (1)
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1
University Hospital Freiburg, Department of Medicine
Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79104