Status:
COMPLETED
Diabetes Control and Complications Trial (DCCT)
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Type 1 Diabetes Mellitus
Eligibility:
All Genders
13-39 years
Phase:
NA
Brief Summary
Background. Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM). We examined whether intensive treatmen...
Eligibility Criteria
Inclusion
- Eligibility Criteria:
- The major criteria for eligibility included insulin dependence, as evidenced by deficient C-peptide secretion; an age of 13 to 39 years; and the absence of hypertension, hypercholesterolemia, and severe diabetic complications or medical conditions. To be eligible for the primary-prevention cohort, patients were required to have had insulin dependent diabetes mellitus (IDDM) for one to five years, to have no retinopathy as detected by seven-field stereoscopic fundus photography, and to have urinary albumin excretion of less than 40 mg per 24 hours. To be eligible for the secondary-intervention cohort, the patients were required to have IDDM for 1 to 15 years, to have very-mild to moderate nonproliferative retinopathy, and to have urinary albumin excretion of less than 200 mg per 24 hours.
Exclusion
Key Trial Info
Start Date :
August 1 1983
Trial Type :
INTERVENTIONAL
End Date :
April 1 1993
Estimated Enrollment :
1441 Patients enrolled
Trial Details
Trial ID
NCT00360815
Start Date
August 1 1983
End Date
April 1 1993
Last Update
March 2 2010
Active Locations (38)
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1
University of California
La Jolla, California, United States, 92093-0620
2
Yale University School of Medicine
New Haven, Connecticut, United States, 06510
3
University of South Florida College of Medicine
Tampa, Florida, United States, 33612
4
Northwestern University
Chicago, Illinois, United States, 60611