Status:
COMPLETED
Systemic Immunomodulatory Effects and Pharmacogenetics of Atorvastatin in Early Atherosclerosis
Lead Sponsor:
University of Florida
Collaborating Sponsors:
American Heart Association
American College of Clinical Pharmacy
Conditions:
Inflammation
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of the study is to test whether atorvastatin (also known as Lipitor) has anti-inflammatory effects in people with no known heart disease or high cholesterol. We also are investigating whet...
Detailed Description
All subjects received 16 weeks of Atorvastatin after a two week run in. Key dependent variables were the 16 week value minus the baseline value (post run-in). Last observation carried forward was used...
Eligibility Criteria
Inclusion
- 18+ years old
- Normocholesterolemic
Exclusion
- Cardiovascular disease or risk equivalents
- Malignancy
- Active alcohol abuse
- Contraindications to statins
- Interacting drugs
- Chronic anti-inflammatory drugs
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2009
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT00361283
Start Date
June 1 2004
End Date
January 1 2009
Last Update
May 15 2012
Active Locations (1)
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1
University of Florida
Gainesville, Florida, United States, 32610