Status:
COMPLETED
Human MATER and Idiopathic Infertility
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Infertility
Eligibility:
FEMALE
Brief Summary
Approximately 15 percent of couples experience infertility, yet no abnormalities can be detected in the man or the woman. In a number of couples, their embryos unexpectedly slow down growth or stop gr...
Detailed Description
The pilot investigation will examine the hypothesis that human infertility may be caused by mutations in the human MATER gene. We will determine the prevalence of these mutations in a select group of ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Women to be included in this study will have a clinical infertility history that would be consistent with a possible defect in a maternal effect gene.
- This includes women who meet the following criteria:
- a clinical diagnosis of infertility,
- never been pregnant, and
- undergone treatment by in vitro fertilization and had at least 8 fertilized eggs as part of at least one in vitro fertilization cycle that failed to lead to a clinical pregnancy.
- Women who have subsequently achieved a pregnancy by egg donation will be included.
- Women of any age are eligible as long as they have otherwise met the inclusion criteria.
Exclusion
Key Trial Info
Start Date :
May 3 2002
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 29 2011
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00361816
Start Date
May 3 2002
End Date
March 29 2011
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892