Status:
WITHDRAWN
Topical Morphine for Analgesia in Patients With Skin Grafts
Lead Sponsor:
Rambam Health Care Campus
Conditions:
Skin Transplantation
Pain
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
The management of pain endured by patients after skin grafting is complex. Pain is the single most distressing symptom but as it is difficult to manage, it is often under-treated. These patients may e...
Detailed Description
Administration of morphine into the knee joint is the best-studied clinical procedure documenting the use of topically-applied opioids. When 1-5 mg morphine were injected into the knee joint, patients...
Eligibility Criteria
Inclusion
- Patients undergoing skin-grafting
- American Society of Anesthesiologists (ASA) classification I-II
- Written consent
- Either sex
- Able to self-asses and report their pain level
Exclusion
- Alcohol abuse or addiction - current
- Opioids and benzodiazepines abuse - life time
- Known hypersensitivity to morphine
- Major renal or hepatic dysfunction
- Pregnancy or lactation
- Sleep-apnoea-syndrome
- Diabetes
- Participation in other clinical studies
Key Trial Info
Start Date :
January 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2024
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00362219
Start Date
January 1 2022
End Date
December 1 2024
Last Update
May 3 2022
Active Locations (1)
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1
Department of Plastic Surgery, Rambam Medical Center
Haifa, Israel, 31096