Status:
COMPLETED
Topical Sunscreen in Preventing Skin Rash in Patients Receiving Drugs Such as Erlotinib or Cetuximab for Cancer
Lead Sponsor:
Alliance for Clinical Trials in Oncology
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Dermatologic Complications
Unspecified Adult Solid Tumor, Protocol Specific
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
RATIONALE: Topical sunscreen may be effective in preventing skin rash caused by treatment with drugs such as erlotinib or cetuximab. It is not yet known whether topical sunscreen is more effective tha...
Detailed Description
OBJECTIVES: * Compare the incidence and severity of erlotinib-, cetuximab-, or other epidermal growth factor receptor inhibitor-induced skin rash development in patients with cancer treated with prop...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Diagnosis of cancer
- Receiving ≥ 1 of the following epidermal growth factor receptor (EGFR) inhibitor treatments:
- Gefitinib
- Cetuximab
- Erlotinib
- Panitumumab
- ICR-62
- Matuzumab
- CI-1033
- EGFR treatment must have begun within the past 3 days
- No rash (of any etiology) at study entry
- PATIENT CHARACTERISTICS:
- Able to apply sunscreen on face, trunk, and extremities
- Able to complete questionnaire(s)
- No history of allergic reactions or severe intolerance to sunscreen or its derivatives
- No history of skin problems likely to reoccur during treatment
- Must avoid heavy sun exposure, especially during the hours of noon to 4 pm daily
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No concurrent tanning bed usage
- No other concurrent topical sunscreens
Exclusion
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2009
Estimated Enrollment :
116 Patients enrolled
Trial Details
Trial ID
NCT00362986
Start Date
October 1 2006
End Date
October 1 2009
Last Update
December 13 2016
Active Locations (208)
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1
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States, 32224
2
Rush-Copley Cancer Care Center
Aurora, Illinois, United States, 60507
3
St. Joseph Medical Center
Bloomington, Illinois, United States, 61701
4
Graham Hospital
Canton, Illinois, United States, 61520