Status:
COMPLETED
Validation of Laser Doppler Flowmetry to Identify Allergic Rhinitis Patients With Pharmacogenetic Alterations in Histamine Metabolism
Lead Sponsor:
Children's Mercy Hospital Kansas City
Conditions:
Allergic Rhinitis
Eligibility:
All Genders
7-18 years
Brief Summary
The hypothesis to be proven is that histamine iontophoresis with measurement of microvascular blood flow by laser Doppler flowmetry can be used as a reliable marker to characterize the normal microvas...
Detailed Description
The specific aim of this study is to validate iontophoresis (with measurement of microvascular blood flow by laser Doppler flowmetry) in a pediatric cohort as a surrogate marker capable of reliably ch...
Eligibility Criteria
Inclusion
- Established diagnosis of allergic rhinitis and/or allergic conjunctivitis, and/or allergic asthma either clinically (by presence of rhinitis and/or conjunctivitis with or without associated wheezing) and/or with a positive RAST/skin test to the following allergens: trees, grass, weeds, molds, cat, dog, dust mites and/or cockroach)
Exclusion
- Previous history or laboratory evidence of McCune Albright syndrome, immunodeficiency, mastocytosis, receipt of immunomodulatory treatment, chronic conditions associated with abnormalities of the integument, hepatic or renal compromise, neoplastic disease, movement or neurologic disorders and uncontrolled ADHD
- Active atopic dermatitis at the site of the skin prick test or site where histamine iontophoresis will be performed, i.e. active atopic dermatitis on anterior forearms
- History of anaphylaxis or anaphylactic like episode
- Evidence of pregnancy (by urinary hCG) or lactation
- Use of drugs (within a specified time period) of agents capable of altering the response to histamine provocation (e.g., antihistamines, systemic corticosteroids, tricyclic antidepressants)
- Presence of any condition that, in the opinion of the investigator, would produce difficulty with adherence to study procedures.
Key Trial Info
Start Date :
August 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2024
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT00362999
Start Date
August 1 2006
End Date
July 1 2024
Last Update
July 3 2024
Active Locations (1)
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1
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108