Status:
WITHDRAWN
Arterial Stiffness and Calcifications in Haemodialysis Patients on Sevelamer or Calcium Acetate
Lead Sponsor:
Romanian Society of Nephrology
Conditions:
Haemodialyzed Patients
Hyperphosphatemia
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
End-stage renal disease (ESRD) is a state of increased arterial stiffness of extensive vessel calcifications, compared with the non-renal population. Both arterial stiffness and arterial calcification...
Detailed Description
End-stage renal disease (ESRD) is a state of increased arterial stiffness of extensive vessel calcifications, compared with the non-renal population. Both arterial stiffness and arterial calcification...
Eligibility Criteria
Inclusion
- more than 3 months on haemodialysis
- willingness to participate
- age 18-60 yrs
- pre-dialysis blood pressure 120-160 mmHg in the last month prior to the initiation of study or recent (\<1 Mo) addition of a new antihypertensive drug
- iPTH at entry 200-800 pg/mL (as per severe hyperparathyroidism)
- serum calcium at entry 2.2-2.6 mmol/L
Exclusion
- haemodynamic instability
- uncontrolled hypertension
- any severe, debilitating disease associated with a reduced survival
- any major cardiovascular event in the last 12 month before study
- cinacalcet therapy before study entrance
- history of parathyroidectomy
- documented history of poor compliance
- serious gastrointestinal disease
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2017
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00364000
Start Date
January 1 2012
End Date
December 1 2017
Last Update
December 22 2017
Active Locations (2)
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1
"Dr Carol Davila" Teaching Hospital of Nephrology
Bucharest, Romania, 010731
2
"CI Parhon" Clinical Hospital
Iași, Romania