Status:
COMPLETED
Incretins in Impaired Fasting Glucose
Lead Sponsor:
Mayo Clinic
Conditions:
Pre-diabetes
Eligibility:
All Genders
35-70 years
Phase:
PHASE4
Brief Summary
People with high fasting glucose can develop type 2 diabetes with the passage of time. This study is being done to determine the effect of a novel medication in people with this elevated fasting gluco...
Detailed Description
Impaired fasting glucose (IFG) confers a high risk of progression to diabetes. Its pathogenesis has been an area of active investigation, with defects in insulin and glucagon secretion as well as insu...
Eligibility Criteria
Inclusion
- Twenty four participants aged 35 to 70 years with impaired fasting glucose (100mg/dl-125 mg/dl) will be studied.
- Males and females between the ages of 35-70.
- Good health as determined by past medical history,physical examination, vital signs, electrocardiogram and laboratory tests at the time of screening.
- Patients on diuretics or thyroid hormone therapy must be on a stable dose (at least 3 months prior to screening) and the maintenance dose may not be adjusted during the study.
Exclusion
- Individuals with a body mass index less than 19 or greater than 40 kg/m\^2, or a total weight \> 130 kg, will be excluded from study.
- Subjects less than 35 years will not be studied in order to minimize the possibility of studying subjects with type 1 diabetes.
- No history of a) significant nephropathy, (i.e., plasma creatinine \> 1.4 mg/dl in women and 1.5 mg/dl in men, and/or proteinuria); b) clinically significant atherosclerotic vascular disease (e.g., history of heart attack or angina); c) a known systemic illness.
- Pregnant or lactating females.
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00364377
Start Date
August 1 2006
End Date
December 1 2008
Last Update
December 6 2011
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905