Status:
COMPLETED
Moderate Alcohol Consumption, Fat and Carbohydrate Metabolism and Insulin Sensitivity
Lead Sponsor:
TNO
Collaborating Sponsors:
Dutch Foundation for alcohol research
Conditions:
Diabetes Mellitus, Type 2
Cardiovascular Disease
Eligibility:
MALE
18-40 years
Phase:
NA
Brief Summary
Moderate alcohol consumption is associated with a decreased risk of diabetes type 2. This association could be mediated by an improvement of insulin sensitivity with moderate alcohol consumption. Pati...
Detailed Description
To investigate the effect of moderate alcohol consumption on * enzymes involved in fatty acid oxidation, oxidative phosphorylation and glycolysis in skeletal muscle * transporters of fatty acids and ...
Eligibility Criteria
Inclusion
- Healthy men aged between 18 and 40 years
- Lean subjects BMI 18.5-25 kg/m2 and overweight/obese subjects BMI \>27 kg/m2 (including 18.5, 25 and 27)
- Alcohol consumption between 7 and 28 units/week (including 7 and 28)
Exclusion
- Smoking
- Family history of alcoholism
- History of medical or surgical events that may significantly affect the study outcome, particularly metabolic or endocrine disorders and gastrointestinal disorders
- Recent blood donation
- More than 8 hours/week of intense exercise
- Blood haemoglobin concentration below 8.4 mmol/l
- Allergic to betadine or lidocaine.
Key Trial Info
Start Date :
October 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2004
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00364767
Start Date
October 1 2004
End Date
December 1 2004
Last Update
May 23 2008
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