Status:
COMPLETED
A Multicenter Study of the Efficacy of Cerezyme in Testing Skeletal Disease in Patients With Type I Gaucher Disease.
Lead Sponsor:
Genzyme, a Sanofi Company
Conditions:
Gaucher Disease Type I
Cerebroside Lipidosis Syndrome
Eligibility:
All Genders
10-65 years
Phase:
PHASE4
Brief Summary
This is a multicenter, open-label, prospective study of the efficacy of Cerezyme in treating patients with skeletal manifestations secondary to Type I Gaucher disease. The study objective is to evalu...
Eligibility Criteria
Inclusion
- Signed informed consent.
- Confirmed diagnosis of Type I Gaucher disease, with no prior enzyme replacement therapy, gene therapy or bone marrow transplantation, and who are ambulatory.
- Age 10-65 (patients 66-70 years of age are considered on a case-by-case basis following careful medical review).
- Dual energy X-ray absorptiometry (DEXA) of the femoral nech with a T-score ≤ -1.0.
- One of more of the following signs as documented by X-ray, computed tomography (CT), or magnetic resonance imaging (MRI), or symptoms of bone disease as documented in the patient's medical history or baseline examinations: a). history of at least one bone crises; b). Erlenmeyer flask deformity of the femora in children (10-17 years old); c). osteoarticular necrosis; d). medullary infarctions; e). lytic lesions; f). pathological fractures or fractures related to Gaucher disease; g). marrow infiltration to a degree such that Rosenthal's Magnetic Resonance Score was ≥ 3; h). bone density by quantitative computed tomography (QCT) or DEXA ≥ 1.5 standard deviation (SD) below age-adjusted normal value; and i). fat fraction ≤ 17%.
Exclusion
- More than 1 joint replacement (revision surgery such as repair or replacement of a previously replaced joint is allowed).
- Pregnant, lactating or per-menopausal women.
- Active, uncontrolled infection, such as hepatitis B, hepatitis C or human immunodeficiency virus (HIV).
- Major concurrent disorders (i.e. cancer, renal disease) or disorders known to affect bone (e.g. uncontrolled thyroid disease, hyperparathyroidism, hypoparathyroidism, gastrectomy, malabsorption, inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis).
- Medications known to affect bone homeostasis (e.g. chronic oral corticosteroids, anticonvulsants, phenytoin and phenobarbital, hyper-physiological doses of estrogen, defined as \> 0.625mg, or androgens, bisphosphates, calcitonin) within the first 2 months of the first Cerezyme infusion.
- Emotional, behavioral or psychological problems, which in the judgment of the principal investigator, would interfere with the patient adequately complying with the requirement of the study.
Key Trial Info
Start Date :
December 1 1997
Trial Type :
INTERVENTIONAL
End Date :
July 1 2004
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00365131
Start Date
December 1 1997
End Date
July 1 2004
Last Update
March 5 2015
Active Locations (1)
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1
Coral Springs, Florida, United States, 33065