Status:
COMPLETED
Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Pulmonary Disease
Oropharyngeal Disease
Eligibility:
All Genders
18-99 years
Brief Summary
This study will examine bacteria and toxins in the mouth, lung and digestive system that may be the cause of various diseases or symptoms. H. pylori is a bacterium that produces various toxins that ma...
Detailed Description
Vacuolating cytotoxin A (VacA toxin), an 88-kDa multifunctional protein, and other toxins are produced by Helicobacter pylori. We hypothesize that H. pylori, VacA toxin, and other toxins within the ga...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Individuals who are 18 years of age or older with or without a history of gastrointestinal disease and with any of the following:
- lymphangioleiomyomatosis, or
- asthma, or
- sarcoidosis, or
- pulmonary fibrosis, or
- other chronic or genetic lung diseases (e.g., chronic obstructive pulmonary disease, eosinophilic granuloma, cystic fibrosis, Wegener's granulomatosis, chronic bronchitis), or
- research volunteers without a history of lung disease.
- EXCLUSION CRITERIA:
- Individuals with any of the following:
- uncontrolled ischemic heart disease, or
- uncorrectable bleeding diathesis, or
- pregnancy or lactation, or
- inability to give informed consent, or
- risk factors for endocarditis (e.g., prosthetic cardiac valve, previous bacterial endocarditis, surgically constructed systemic pulmonary shunts or conduits, complex cyanotic congenital heart disease \[e.g., single ventricle, transposition of great arteries, tetralogy of Fallot\])
Exclusion
Key Trial Info
Start Date :
September 18 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 27 2016
Estimated Enrollment :
157 Patients enrolled
Trial Details
Trial ID
NCT00366509
Start Date
September 18 2006
End Date
October 27 2016
Last Update
August 2 2021
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892