Status:
TERMINATED
Respiratory Motion Analysis in Children With MRI
Lead Sponsor:
Emory University
Conditions:
Congenital Disorders
Eligibility:
All Genders
Brief Summary
The purpose of this project is to analyze the respiratory motion process as relevant in cardiac MRI imaging and apply the results for development of improved imaging methods and software correction. T...
Detailed Description
Cardiac magnetic resonance imaging (MRI) is used heavily in the research setting but its use is limited in clinical practice, the main reason being artifact (noise) from respiratory and cardiac motion...
Eligibility Criteria
Inclusion
- We will recruit two groups of patients - 35 healthy volunteers (21 years or older) and 25 cardiac MRI patients of different age groups.
- We wish to recruit cardiac patients from Children's Healthcare of Atlanta into five (5) different categories defined by the overall characteristics of breathing motion. The categories are:
- neonates/infants (shallow belly breathing)
- young children (unable to do controlled breathing or breath-holding on command, up to approximately 7 years of age)
- older children capable of controlled breathing/breath-holding on command (approximately 8-12 years of age)
- teenagers/adolescents/young adults (ages 13 through 17)
- adults (18 and older) These categories may be adjusted or modified during the project as deemed appropriate based on the analysis results.
- We will recruit 10 - 35 healthy volunteer subjects for scans to define the MRI imaging protocol for respiratory motion monitoring. Healthy subjects are defined as those individuals who do not have a prior history of heart or lung disease nor are currently diagnosed with heart or lung disease. This information will be obtained verbally during the subject screening process.
Exclusion
- No exclusion criteria will be placed on any sub-population based on age, gender or race other than the patient not freely giving written informed consent or having a history or current diagnosis of heart or lung disease. However, the normal exclusion criteria for MRI exams will still be adhered to:
- subjects with pacemakers, medical implants, aneurysm clips, or imbedded metal fragments will be excluded because of potential effects of the magnetic field
- women who are pregnant or who may be pregnant will be excluded because of the potential of a high level of RF power deposition on the fetus
- subjects who may experience claustrophobia will be excluded because of their inability to remain in the magnet for the time required to complete the exam
Key Trial Info
Start Date :
August 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT00367354
Start Date
August 1 2006
End Date
July 1 2011
Last Update
December 9 2014
Active Locations (1)
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1
Emory University Hospital
Atlanta, Georgia, United States, 30322