Status:
COMPLETED
Erlotinib + Bevacizumab for PS 2 Chemotherapy Naïve Non-Small Cell Lung Cancer
Lead Sponsor:
Nasser Hanna, M.D.
Collaborating Sponsors:
Genentech, Inc.
Walther Cancer Institute
Conditions:
Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The strategy for combining therapeutic agents in cancer treatments has been successful in multiple tumor types, including NSCLC. Erlotinib and bevacizumab target different pathways involved in tumor g...
Detailed Description
OUTLINE: This is a multi-center study. * Bevacizumab 15 mg/kg IV on day 1 * Erlotinib 150 mg po qd days 1-21 * Disease Assessment during even numbered cycles If no progressive disease observed, cont...
Eligibility Criteria
Inclusion
- Histological proof of non-small cell lung cancer meeting one of the following criteria:
- stage III b with a pleural effusion
- stage IV
- Histology must not be squamous cell.
- No prior chemotherapy or hormonal therapy.
- Prior radiation therapy must be completed at least 21 days prior to being registered for protocol therapy.
- No prior use of an epidermal growth factor receptor (EGFR) inhibitor or antiangiogenic agent.
- No treatment with any investigational agent within 30 days prior to being registered for protocol therapy.
- Measurable disease according to RECIST and obtained by imaging within 28 days prior to being registered for protocol therapy.
- ECOG Performance Status of 2 in the opinion of the treating investigator.
- Age \> 18 years at the time of consent.
- Females of childbearing potential and males must be willing to use an effective method of contraception (hormonal or barrier method of birth control; abstinence) while on treatment and for a 6 week period thereafter.
- Females of childbearing potential must have a negative pregnancy test within 7 days prior to being registered for protocol therapy. Subjects are considered not of child bearing potential if they are surgically sterile (they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal.
- Females must not be breastfeeding.
- Able to comply with study and/or follow-up procedures.
Exclusion
- Evidence of bleeding diathesis or coagulopathy.
- Evidence of central nervous system involvement or brain metastases confirmed by head CT or brain MRI within 28 days prior to being registered for protocol therapy.
- Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to registration for protocol therapy.
- Anticipation of need for major surgical procedure during the course of the study.
- Minor surgical procedures such as fine needle aspirations or core biopsies within 7 days prior to registration for protocol therapy.
- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to registration for protocol therapy.
- Serious, non-healing wound, ulcer, or bone fracture.
- History of hemoptysis.
- Clinically significant infections as judged by the treating investigator.
- Other active malignancy
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00367601
Start Date
August 1 2006
End Date
December 1 2008
Last Update
February 11 2016
Active Locations (13)
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1
Medical & Surgical Specialists, LLC
Galesburg, Illinois, United States, 61401
2
Cancer Care Center of Southern Indiana
Bloomington, Indiana, United States, 47403
3
Oncology Hematology Associates of SW Indiana
Evansville, Indiana, United States, 47714
4
Fort Wayne Oncology & Hematology, Inc
Fort Wayne, Indiana, United States, 46815