Status:
COMPLETED
Hypersensitivity in Tourette Syndrome
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Tourette's Syndrome
Eligibility:
All Genders
18-65 years
Brief Summary
This study will investigate how the sensitivity to touch and smell in patients with Tourette syndrome (TS) may differ from that of people without TS. TS is a neurological disorder that causes people t...
Detailed Description
OBJECTIVE: This study will explore sensory phenomena associated with Tourette syndrome (TS). The first part will evaluate threshold levels versus perceived intensity of tactile and olfactory stimuli ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy Volunteers ages 18 to 65 who have who have given their consent.
- Patients will be ages 18 to 65 and have clinically documented Tourette's syndrome or chronic motor tic disorder as defined by DSM-IV-TR (American Psychiatric Association, 2000) and evaluation of tic severity using the Yale Tic Scale (YGTS). This criterion will be established by preliminary screening in the NINDS Movement Disorders Outpatient Clinic. Structure Clinical Interview for (DSMIV SCID) will be administered to all patients to ensure that strict DSM-IV criteria for Tourette Syndrome have been met and to assess for possible comorbid psychiatric disorders.
- Patients with at least moderate premonitory urge, as evaluated with the PUTS.
- EXCLUSION CRITERIA:
- Subjects younger than 18 or older than 65 years.
- Subjects with 1) major depression, 2) bipolar disorder, or 3) psychotic disorder.
- Subjects who are unable to abstain from alcohol or any psychiatric medications 24 hours prior to the study.
- Subjects with acute or chronic upper respiratory illness, nasal allergies, or subjects using medications to treat these conditions, including antihistamines, nasal topical steroids, vasoconstrictor nasal sprays, or normal saline sprays.
- Women who are pregnant.
- Individuals with Restless Legs syndrome.
- Individuals with a diagnosis of peripheral neuropathy.
Exclusion
Key Trial Info
Start Date :
August 21 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 24 2011
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT00368433
Start Date
August 21 2006
End Date
May 24 2011
Last Update
July 2 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892