Status:
COMPLETED
Evaluate Whether Combination Therapy With Methotrexate and Raptiva in Psoriasis Patients is Safe and Increases Efficacy
Lead Sponsor:
University of California, Davis
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Psoriasis
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
To evaluate whether a short-term course of methotrexate in patients treated with efalizumab (Raptiva) increases efficacy. The secondary objectives of this study are 1) to evaluate the efficacy of Rapt...
Detailed Description
The primary objective of this study is to evaluate whether a short-term course of methotrexate in patients treated with efalizumab (Raptiva) increases efficacy. The secondary objectives of this study ...
Eligibility Criteria
Inclusion
- Moderate to severe plaque-type psoriasis
- A candidate for systemic therapy or phototherapy
- Not using prescription systemic therapies for psoriasis prior to starting the study
- Not using efalizumab within 3 months prior to starting the study
- We are seeking adults who:
- Have moderate to severe plaque-type psoriasis
- Are generally healthy
- Are not hypersensitive to Raptiva® (efalizumab) or any of its components.
- Are not pregnant or lactating women
- You will:
- Be interviewed and examined
- Have blood drawn
- Be injecting the study medication
Exclusion
- Hypersensitivity to Raptiva or any of its components
- Pregnant or lactating women
- History of liver disease or abnormal liver enzymes
- History of chronic infection or malignancy
- History of significant hematologic abnormalities
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2008
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00368654
Start Date
January 1 2007
End Date
May 1 2008
Last Update
June 14 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of California, Davis Medical Center Department of Dermatology
Sacramento, California, United States, 95816