Status:
COMPLETED
Energy Homeostasis in Anorexia Nervosa
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Anorexia Nervosa
Eligibility:
FEMALE
18-45 years
Brief Summary
The purpose of this study is to investigate the potential biological predispositions that contribute to the difficulty patients with anorexia nervosa have in maintaining normal weight.
Detailed Description
Anorexia Nervosa (AN) is a psychiatric illness that is characterized by extreme weight loss and severe body image distortions. In this study, we are examining changes in body composition, metabolic ra...
Eligibility Criteria
Inclusion
- Patients:
- DSM-IV diagnosis of Anorexia Nervosa
- BMI ≤ 17.5kg/m2 (equivalent to 80% of ideal body weight)
- Medically stable
- Participation in in-patient treatment sufficient to restore patient to a BMI of at least 19kg/m2
Exclusion
- On medication\*
- Current substance abuse or dependence
- History of suicide attempt or other self-injurious behavior within the previous 6 months
- Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos)
- Controls:
- Inclusion criteria:
- No current psychiatric disorder (including eating disorder, depression, bipolar disorder, schizophrenia, substance abuse/dependence)
- No history of an eating disorder
- BMI greater than 19kg/m2 and less than 21kg/m2
- Weight stable (+/- 2kg) for the previous 6 months
- No history of excessive or repeated dieting
- No history of excessive exercise (defined as greater than 6 hours/week)
- Regular menstrual cycles
- Exclusion criteria:
- On medication\*
- Pregnant or lactating
- Significant medical problem
- Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos)
- At the time of testing, subjects will be free of fluoxetine for 6 weeks, and free of all other medications for a minimum of 2 weeks
Key Trial Info
Start Date :
April 1 2000
Trial Type :
OBSERVATIONAL
End Date :
December 1 2004
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00368667
Start Date
April 1 2000
End Date
December 1 2004
Last Update
January 13 2010
Active Locations (1)
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1
New York State Psychiatric Institute, Unit 98
New York, New York, United States, 10032