Status:
COMPLETED
Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism.
Lead Sponsor:
Finnish Institute for Health and Welfare
Collaborating Sponsors:
Finnish Foundation for Alcohol Studies
Conditions:
Alcoholism
Depression
Eligibility:
All Genders
25-70 years
Phase:
PHASE4
Brief Summary
The aim of the present study was to examine the influence of memantine, a noncompetitive NMDA receptor blocker, in depression co-morbid with long term alcohol heavy use comparing to SSRI-inhibitor, es...
Detailed Description
Context Depression is common clinical problem among alcoholics and its treatment has no standard and is controversy. Glutamate NMDA-receptors may mediate the effects of long term alcohol related depre...
Eligibility Criteria
Inclusion
- The subject/patient is able to read and understand the subject/patient information sheet.
- Prior to any screening procedures, the subject/patient must have signed the informed consent form. No study-related procedures may be performed before the subject/patient has signed the form.
- Age 25-70 years
- Heavy alcohol consumption (males more than 5 doses/ day, female more than 4 doses/day) for at least 10 years
- Alcohol dependence (DSM-IV) assessed by SCID-I interview.
- Major depression (DSM-IV) assessed by SCID-I interview. At least 4 weeks past from the previous inpatient treatment for AWS (alcohol withdrawal syndrome).
Exclusion
- Other drug dependence (screened by urine test)
- Other serious mental illness (DSM-IV)
- Hazard of suicide
- Pregnancy
- Serious kidney, hart or thyroid problem
- The subject/patient, in the opinion of the investigator, is unlikely to comply with the clinical study protocol or is unsuitable for any reason.
- Liver cirrhosis or liver enzymes ASAT tai ALAT \>200.
- The person that met the criteria stated in the Finnish Law on Clinical Studies, paragraph 7-10§ (children, pregnant, imamates or mentally handicapped).
Key Trial Info
Start Date :
December 1 2005
Trial Type :
INTERVENTIONAL
End Date :
June 1 2006
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00368862
Start Date
December 1 2005
End Date
June 1 2006
Last Update
August 29 2006
Active Locations (1)
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1
National Public Health Institute, Department of Mental Health and Alcohol Research
Helsinki, POB 33, Finland, 00251