Status:
SUSPENDED
Prednisone for Decompensated Congestive Heart Failure
Lead Sponsor:
Hebei Medical University
Conditions:
Heart Failure, Congestive
Eligibility:
All Genders
18-90 years
Phase:
PHASE2
PHASE3
Brief Summary
We designed this, randomized, double-blind, placebo-controlled trial to determine the clinical efficacy of chronic administration of prednisone on renal function and clinical status when added to stan...
Detailed Description
Studies showed that glucocorticoids could specifically dilate renal vessel, increase in GFR, and regulate synthesis and release of atrial natriuretic peptide (ANP), upregulate ANP receptors on vascula...
Eligibility Criteria
Inclusion
- Hospitalized with primary diagnosis of CHF
- Patients with normal cortical function
- LVEF \<40%
- Significant fluid overload, defined as ≥ 2 of the following
- Enlarged liver or ascites
- Peripheral or sacral edema ( ≥ 2+)
- Jugular venous distention ≥ 10 cm
- Pulmonary rales, pleural effusion on chest x-ray or orthopnea
Exclusion
- Severe stenotic valvular disease
- Serum creatinine \> 4 mg/dl
- Patient refusal
- Any signs of infection or any condition that would contraindicate an glucocorticoids use
- Poor controlled hypertension
- Poor controlled diabetes mellitus
- Active myocarditis
- Malignancy or other terminal illness
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2008
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00369044
Start Date
October 1 2006
End Date
July 1 2008
Last Update
April 8 2009
Active Locations (1)
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1
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050031