Status:
TERMINATED
A Study of Volociximab in Metastatic Melanoma
Lead Sponsor:
Abbott
Collaborating Sponsors:
Biogen
Conditions:
Stage IV Melanoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This is a Phase 2, multicenter, research study determining the effects of an investigational drug called volociximab in metastatic melanoma. The purpose of the study is to compare the clinical benefi...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Must give written informed consent and any authorizations required by local law (e.g., Protected Health Information \[PHI\]).
- Aged \>=18 years old at the time of informed consent.
- Stage III and Stage IV unresectable melanoma with documented progression during or following the most recent prior melanoma therapy.
- Must have failed at least 1 prior therapy for metastatic disease.
- Must have at least 2 cutaneous, subcutaneous, or nodal metastases that are safely accessible for pre treatment and post treatment biopsies.
- Must agree to pre-treatment and post-treatment biopsies of tumor lesions (subjects in Stage 1 only).
- Must have at least 1 measurable target lesion for CT/MRI assessment, according to RECIST criteria.
- ECOG Performance Status \<=1.
- Acceptable laboratory results
- Life expectancy \>=12 weeks.
- Male subjects and female subjects of child bearing potential must be willing to practice effective contraception during the study and be willing and able to continue contraception for 4 months after last infusion of study treatment.
- Exclusion Criteria
- Subjects with any other active malignancy in addition to metastatic melanoma.
- CNS metastases, unless stable for at least 2 months following definitive local therapy (surgery, stereotactic radiation). Subjects may not require treatment with steroids or anticonvulsants.
- History of any other significant medical condition, including cardiovascular, pulmonary, neurologic, or autoimmune disease; active infections (e.g., bacterial or fungal); or a psychiatric condition within 6 months of Day 1
- History of hepatitis B or C.
- Known history of HIV infection or AIDS.
- History of thromboembolic or cerebrovascular events, such as stroke, transient ischemic attack, deep vein thrombosis, or bleeding disorders within 12 months prior to Day 1.
- Prior radiation therapy, chemotherapy, hormonal therapy, or immunotherapy for melanoma within 4 weeks prior to Day 1.
- Previous exposure to volociximab.
- Aspirin, high dose warfarin, or heparin use. (Note: Aspirin \<=81 mg/day, low-dose warfarin 1 mg/day or low-dose heparin for IV catheter patency is allowed.)
- Major surgery within 4 weeks prior to Day 1.
- Requirement for immunosuppression, and/or systemic steroid therapy.
- Investigational therapies within 4 weeks prior to Day 1 or 4 half lives of the prior investigational drug (whichever is longer).
- Known hypersensitivity to murine or chimeric antibodies.
- Any condition that, in the opinion of the Investigator, makes the subject unsuitable for study participation.
- Female subjects who are pregnant or currently breastfeeding.
Exclusion
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2008
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00369395
Start Date
December 1 2006
End Date
March 1 2008
Last Update
April 27 2012
Active Locations (7)
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1
Site Reference ID/Investigator# 70357
Scottsdale, Arizona, United States, 85258
2
Site Reference ID/Investigator# 70356
La Jolla, California, United States, 92093
3
Site Reference ID/Investigator# 70375
Aurora, Colorado, United States, 80045
4
Site Reference ID/Investigator# 70376
Boston, Massachusetts, United States, 02115