Status:
RECRUITING
Diagnosis and Treatment of Patients With Inborn Errors of Metabolism
Lead Sponsor:
National Human Genome Research Institute (NHGRI)
Conditions:
Arterial Calcification Due to Deficiency of CD73
Eligibility:
All Genders
1-115 years
Brief Summary
Researchers intend on diagnosing and treating certain inborn errors of metabolism. By doing this researchers hope to expand their knowledge about these disorders and provide access to patients of inte...
Detailed Description
Study Description: We propose to characterize the etiology and natural history of rare inborn errors of metabolism and other genetic disorders, both known and yet-to-be discovered. In so doing, we wi...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Participants 1 month or older will have been or will be referred to this protocol with a known or suspected inborn error of metabolism, heritable disorder, or genetic predisposition. Participants over two years of age will be admitted only if they are medically stable and require admission to the Clinical Center for diagnosis. Children ages 1 month to 2 years or under 12 kg will be reviewed by the Pediatric Consult Service prior to scheduling and if approved will be evaluated.
- Examples of disorders that will be under this protocol include inherited developmental defects or diatheses toward infections, cancer, or an environmentally induced disease. The principal investigator, along with consulting specialists, will review the medical records of prospective participants and offer admission based upon the potential to help the individual, to learn from the participant, or to initiate clinical or basic research suggested by the participant s workup. This protocol is not intended to serve as an umbrella protocol for small studies of specific disorders. In general, no more than 5 families known to have the same disorder will be investigated under this protocol.
- Some participants will be relatives of patients with known diagnoses, and their specimens will be obtained for the purpose of heterozygote testing or to serve as controls to help diagnose the proband. All participants shall be seen as inpatients, outpatients or via Telehealth at the discretion of the principal investigator, based upon particular research interests and expertise. Normal adult volunteers aged 18 years or older will be enrolled to provide control blood and urine specimens.
- EXCLUSION CRITERIA:
- Participants under 1 month of age will not be seen at the NIH Clinical center because care is more readily proffered to older individuals at the Clinical Center.
- Participants over two years of age will not be admitted if they are medically unstable and do not require admission to the Clinical Center for diagnosis.
- Pregnant women are excluded.
Exclusion
Key Trial Info
Start Date :
September 12 1978
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
4000 Patients enrolled
Trial Details
Trial ID
NCT00369421
Start Date
September 12 1978
Last Update
December 19 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892